Understanding s-LDSC Boosts Statistical Precision in Genomic Studies
Summary The objective is to move beyond global LD Score Regression (LDSC) to understand how specific biological processes contribute to heritability. While standard LDSC provides a single intercept representing overall polygenicity, Stratified LDSC (s-LDSC) allows us to perform partition correlation analysis. This process quantifies the extent to which genetic signal is enriched within specific functional … Read more